Project
Nutrition and immunity
The field of nutrition and immunity studies how the foods we eat can affect our immune health. It is known that food can either cause disease or prevent the occurrence of diseases. For this reason we are very interested in studying effects of food components on the immune system.
Background
Given the increases of population and trends of urbanization and ageing, the healthcare system is facing several challenges in relation to the increase of inflammation related diseases (chronic inflammatory diseases, allergies, autoimmunity) as well as an increasing part of the population that is susceptible to infections (elderly and the very young). The role that food can play in human and animal immune health has become more clear over the past few decades. A better understanding of the effects that foods have on our immune system can help to prevent the severity and maybe even the occurrence of some of these diseases.
Project description
The project has 4 different research lines/activities, and will be updated into several projects after the next website update:
- Innate immune training – food components that can induce a better innate immune response when exposed to pathogens
- Effects of food processing and dietary AGE intake on inflammatory diseases.
- Food and gastrointestinal and respiratory immunity
- Milk and immunity (see separate project file “The effect of milk on human immune function”)
Results
We have evaluated immunological effects of milk components, fibers and polysaccharides, and have also evaluated effects of nutritional intervention studies and oral vaccination (plus/minus food intervention) on the presence and function of cells of the immune system.
Publications
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Ingestion, Immunity, and Infection : Nutrition and Viral Respiratory Tract Infections
Frontiers in Immunology (2022), Volume: 13 - ISSN 1664-3224 -
Babies, Bugs, and Barriers : Dietary Modulation of Intestinal Barrier Function in Early Life
Annual review of nutrition (2022), Volume: 42 - ISSN 0199-9885 - p. 165-200. -
Sialyllactose and Galactooligosaccharides Promote Epithelial Barrier Functioning and Distinctly Modulate Microbiota Composition and Short Chain Fatty Acid Production In Vitro
Frontiers in Immunology (2019), Volume: 10 - ISSN 1664-3224 -
Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women : Results from a nutritional intervention study with bovine lactoferrin, GOS and Vitamin D
Frontiers in Immunology (2018), Volume: 9 - ISSN 1664-3224 -
The oligosaccharides 6’-sialyllactose, 2’-fucosyllactose or galactooligosaccharides do not directly modulate human dendritic cell differentiation or maturation
PLoS ONE (2018), Volume: 13, Issue: 7 - ISSN 1932-6203