Project

Organoids as a research tool in animal breeding and nutrition

The main aim of this PPP is to pave the road for high throughput in vitro organoid systems of the pig intestinaltract to use as a key technology in animal breeding and nutrition. The objectives are:- Develop a robust key technology to generate pig intestinal organoids in a high throughput manner- Use organoids to measure nutrient uptake and epithelial (barrier and immune) response therebyconnecting to an animal (in vivo) phenotype- Employ organoids to screen different functional ingredients, including glycolipids (e.g. glucosecaproate) and ligand receptors (e.g. galactooligosaccharides)

The main aim of this PPP is to pave the road for high throughput in vitro organoid systems of the pig intestinal
tract to use as a key technology in animal breeding and nutrition. The objectives are:
- Develop a robust key technology to generate pig intestinal organoids in a high throughput manner
- Use organoids to measure nutrient uptake and epithelial (barrier and immune) response thereby
connecting to an animal (in vivo) phenotype
- Employ organoids to screen different functional ingredients, including glycolipids (e.g. glucose
caproate) and ligand receptors (e.g. galactooligosaccharides)

Publicaties

• Organoids as a research tool in animal breeding and nutrition

  Verschuren, L.M.G. , Schokker, D. , Verstringe, S. , Kruijt, L. , de Wit, A.A.C. , van der Valk, E.G.T. , Kar, S.K. , Ellen, E.D. (2022) In: Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP) - Wageningen: Wageningen Academic Publishers - ISBN: 9789086869404 - p. 2085-2088.