Projects - dr. S (Silvie) Timmers
In my muscle quality research group, I supervise three PhD students and one research assistant on translational human intervention studies with attention for mechanistic working mechanisms. I collect information on the whole-body-, tissue- and cell/mitochondrial level to understand how muscle quality is related to health, and quality of life. I invest time to develop sensitive and non-invasive muscle quality assessment tools, since for scientific discoveries I am dependent on human volunteers. In addition, my team has developed a video explaining the muscle biopsy technique to volunteers, in which also the experience of a test volunteer is shared.
I currently lead a number of research projects aimed at understanding how muscle quality is affected in diseased states (e.g. drug-treatment, inherited metabolic disorders):
Drug-induced muscle function decline
The effects of statins on skeletal muscle function and health
The effects of tyrosine kinase inhibitors on skeletal muscle function and health
Inherited metabolic disorders and muscle health
The impact and feasibility of a modified Atkins diet on skeletal muscle function in mitochondrial disease patients
The impact of aging on muscle quality and possible therapeutics
Designing a ketogenic supplement for muscle health
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Drug-induced muscle function decline
Drug-induced muscle function decline - WUR Project Drug-induced muscle function decline Drugs are prescribed to manage or prevent symptoms and... -
Designing a ketogenic supplement for muscle health
Designing a ketogenic supplement for muscle health - WUR Project Designing a ketogenic supplement for muscle health Aging is arguably the most... -
The metabolic effects of acute [14C]-carbohydrate ingestion in lean and obese individuals
The metabolic effects of acute [14C]-carbohydrate ingestion in lean and obese individuals - WUR Project The metabolic effects of acute...