BEW (Ben) Auxier MSc

Short Profile

Originally from Canada, I completed my BSc and MSc at the University of British Columbia working on the evolution of cytoskeletal proteins in aquatic chytrid fungi. Following this, I moved to the Netherlands where he completed my PhD working with Dr. Duur Aanen on the evolutionary consequences of sexual and social interactions in fungi. Since 2022, Ben has had the role of Assistant Professor at the Laboratory of Genetics. Here I work on two topics: the consequences of individuality of fungi, with particular emphasis on the evolution of fungal viruses, as well as the genetics of agricultural antifungal resistance in a human pathogenic fungus, Aspergillus fumigatus.

Research Interests I: Individuality in fungi

My ongoing work includes characterizing nonself recognitions genes (often call het genes) in both Ascomycetes and Basidiomycetes. These genes prevent fusion between individuals, hypothesized to protect fungal individuals from infections with parasitic genetic elements, like viruses. While most mycoviruses (viruses of fungi) seem to have little effect on the host, this may be related to the fact that fusion is prevented between fungal individuals, selecting for low-virulence but high-transmission. Using both laboratory derived viruses, as well as field collected, I am working to explore the full potential of viral evolution, by experimentally manipulating the ability of individuals to fuse with each other.

Research Interests II: Genetics of agricultural resistance in A. fumigatus

The human pathogenic fungus Aspergillus fumigatus causes significant human disease, listed on the World Health Organization Fungal Pathogen Priority List. This fungus is found growing on decaying plant material, and is particularly successful in agricultural settings in compost piles. During growth in these agricultural environments, it is exposed to many chemicals used in food production/preservation, and resistance to these chemicals appears to be relatively common. Worringly, evolution of resistance to these chemicals can also make these fungi resistant to drugs used in hospitals. If patients are infected by these resistant fungi, there are few options for treatment, and the mortality rate is greatly increased. My work uses genomics and genetics to understand the patterns of evolution to these chemicals, as well as looking at what makes A. fumigatus so sucessful in these settings.

Prospective students

Currently, we are accepting students interested in working on the above projects, or other fungal genetics topics. Feel free to contact me to discuss opportunities.