Publicaties

In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells

Louisse, J.; Fragki, Styliani S.; Rijkers, D.E.M.C.; Janssen, A.W.F.; Staats, M.; Zeilmaker, M.J.; Piersma, A.H.; Luijten, Mirjam; Hoogenboom, L.A.P.; Peijnenburg, A.A.C.M.

Samenvatting

Aims of the study:
To obtain insight into the cellular effects of PFASs on the human liver by
studying concentration-dependent whole genome gene expression
changes in PFOS-exposed HepaRG cells.
• To determine in vitro relative potencies of a series of PFASs (Figure 1)
based on concentration-dependent changes in expression of selected
genes in PFAS-exposed HepaRG cells.