Thesis subject
Targeting energy metabolism of cancer cells
Provide a literature overview of exercise as an anti-cancer therapy. Focus on interventions in model animals and humans, including evidence for the underlying mechanisms that are targeted.
Background: Cancer cells use glycolysis for energy production, rather than oxidative metabolism which occurs in mitochondria. Mitochondrial metabolism of cancer cells is reprogrammed for biosynthesis rather than energy production. Mitochondria are thus a target for anti-cancer interventions. AMP-kinase is a cellular energy sensor that targets mitochondria and can stimulate oxidative metabolism. AMP-kinase is activated by exercise.
Aim: Provide a literature overview of exercise as an anti-cancer therapy. Focus on interventions in model animals and humans, including evidence for the underlying mechanisms that are targeted.