Project
4xD: Vitamin D for preventing Dementia and Depression in Diabetes
The twenty-first century is facing the challenge of an accelerating speed of ageing, and with it an increasing prevalence of ageing-related pathologies. Specific age-related conditions, which predominantly affect older people, include dementia (cognitive decline), depression, prediabetes and diabetes, which all rise sharply with age.
A number of epidemiological human studies suggest there are important links between these pathologies, and that they may even share common nutritional risk factors. One of these, a seemingly novel and very relevant risk factor, is Vitamin D. These findings are important, as it is widely recognized that vitamin D status is suboptimal in older adults. The project 4xD (Vitamin D for preventing Dementia and Depression in Diabetes) focusses on the links between prediabetes and diabetes, dementia and depression on the one hand and vitamin D as a joint and novel predisposing factor for these conditions on the other.
Publications
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Cognitive performance: a cross-sectional study on serum vitamin D and its interplay with glucose homeostasis in Dutch older adults
Journal of the American Medical Directors Association (2015), Volume: 16, Issue: 7 - ISSN 1525-8610 - p. 621-627. -
Vitamin D and cognition in older adults: an update of recent findings
Current Opinion in Clinical Nutrition and Metabolic Care (2015), Volume: 18, Issue: 1 - ISSN 1363-1950 - p. 11-16. -
No role for vitamin D or a moderate fat diet in aging induced cognitive decline and emotional reactivity in C57BL/6 mice
Behavioural Brain Research (2014), Volume: 267 - ISSN 0166-4328 - p. 133-143. -
Marketing the use of 25-hydroxyvitamin D3 to enhance cognition
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Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression
Journal of the American Medical Directors Association (2013), Volume: 14, Issue: 1 - ISSN 1525-8610 - p. 852.e9-852.e17. -
Vitamin D. Do we get enough?
Osteoporis International (2013), Volume: 24, Issue: 5 - ISSN 0937-941X - p. 1567-1577. -
Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study
European Journal of Nutrition (2013), Volume: 52, Issue: 3 - ISSN 1436-6207 - p. 917-925. -
Vitamin D and the association with cognitive performance, cognitive decline, and dementia
In: Diet and Nutrition in Dementia and Cognitive Decline - Oxford: Elsevier - ISBN: 9780124078246 - p. 679-700.