The role of inflammation in metabolic complications

Background: Inflammation has been recognized to influence the development of many metabolic complications. Stimuli such as overnutrition, physical inactivity, and aging may result in cytokine hypersecretion and eventually lead to insulin resistance and diabetes.

Questions: What is the precise role of inflammation in metabolic complications? Is this role influenced by nutritional status? Is there a general mechanism involved or are specific pathways more predominantly activated? Are inflammatory mediators interesting targets for nutritional and therapeutic intervention strategies?

Aims: Integrate results from research papers to create an overview about one or more questions related to this topic (exact topic to be determined with supervisor).