Project
Onbedoelde neveneffecten van nieuwe toepassingen in dieren en micro-organismen
New breeding techniques allow targeted DNA modifications in organisms. The organisms and derived products modified using these technologies fall under the EU Directive for the approval of Genetically Modified Organisms (GMOs). With most new technologies, there are new concerns about the safety of these products for humans and animals. These concerns mainly refer to the unintended effects, which are known to occur when applying these technologies. These effects are, for example, modifications in unintended places in the DNA (also known as off-target modifications).
There is currently an ongoing debate on the safety issues of these new technologies, because scientific data for risk scaling is often lacking. Scientific data and knowledge can be relevant for future discussions on policy development, regulation and safety assessment procedures. In this project, we will evaluate the available literature data on unintended effects in peer-reviewed literature, with a primary focus on genome editing in micro-organisms
New breeding techniques allow targeted DNA modifications in organisms. The organisms and derived products modified using these technologies fall under the EU Directive for the approval of Genetically Modified Organisms (GMOs). With most new technologies, there are new concerns about the safety of these products for humans and animals. These concerns mainly refer to the unintended effects, which are known to occur when applying these technologies. These effects are, for example, modifications in unintended places in the DNA (also known as off-target modifications). There is currently an ongoing debate on the safety issues of these new technologies, because scientific data for risk scaling is often lacking. Scientific data and knowledge can be relevant for future discussions on policy development, regulation and safety assessment procedures.
In this project, we will evaluate the available literature data on unintended effects in peer-reviewed literature, with a primary focus on genome editing in micro-organisms.