Publications

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Oyadomari, Yasumoto; Goto, Yasuyuki; Suganuma, Keisuke; Kawazu, Shin Ichiro; Becking, Leontine E.; Fusetani, Nobuhiro; Nakao, Yoichi

Summary

A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC₅₀ value of 0.74 µM.