Project
GeoLynch - Genetic, Environmental and Other influences among persons with LYNCH syndrome
In the GeoLynch study we would like to learn more about the influence of dietary and lifestyle factors on the development of tumours among persons with Lynch syndrome, who have an inherited high risk of various types of cancer.
Data from persons with Lynch syndrome who develop a tumour are compared to data from persons with Lynch syndrome who do not develop a tumour. By studying whether persons with tumours have a different dietary pattern or lifestyle than persons without tumours, we can investigate whether diet and lifestyle have affected the development of that tumour. The final purpose of the GeoLynch study is to be able to advise persons with Lynch syndrome about diet and lifestyle, so that these persons can do something to reduce their risk of developing cancer.
Links
More research: Nutrition and cancer
More research: Disease aetiology and prevention
Publications
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Is a colorectal neoplasm diagnosis a trigger to change dietary and other lifestyle habits for persons with Lynch syndrome? A prospective cohort study
Familial Cancer (2021), Volume: 20, Issue: 2 - ISSN 1389-9600 - p. 125-135. -
Diet quality and colorectal tumor risk in persons with Lynch syndrome
Cancer Epidemiology (2020), Volume: 69 - ISSN 1877-7821 -
Inflammatory potential of the diet and colorectal tumor risk in persons with Lynch syndrome
American Journal of Clinical Nutrition (2017), Volume: 106, Issue: 5 - ISSN 0002-9165 - p. 1287-1294. -
Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study
Cancer Causes and Control (2014), Volume: 25, Issue: 9 - ISSN 0957-5243 - p. 1119-1129. -
Dietary Patterns and Colorectal Adenomas in Lynch Syndrome: The GEOLynch Cohort Study
Cancer (2013), Volume: 119, Issue: 3 - ISSN 0008-543X - p. 512-521. -
Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study
PLoS ONE (2013), Volume: 8, Issue: 6 - ISSN 1932-6203 -
Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome
Gastroenterology (2012), Volume: 142, Issue: 2 - ISSN 0016-5085 - p. 241-247. -
Body mass index increases risk of colorectal adenomas in men with lunch syndrome: the GEOLynch cohort study
Journal of Clinical Oncology (2010), Volume: 28, Issue: 28 - ISSN 0732-183X - p. 4346-4353.