Magnetic Resonance Imaging (MRI)

Paulien Sterken MSc
Floris Dekker MSc
Dr. Julia Krug
Dr. Tatiana Nikolaeva
Prof. Dr. Aldrik Velders

Magnetic Resonance Imaging (MRI) is well known for being a versatile, non-invasive medical imaging technique. With this method, we mainly extract information coming from the water resonance in tissues. Nuclear Magnetic Resonance (NMR) Spectroscopy is part of every chemist’s toolbox to identify chemical compounds and to look at the chemical environment of multiple different atoms, such as ¹H, ¹³C, ¹⁵N, ¹⁹F, ³¹P etc.

By combining these two approaches at high magnetic field strengths, it is now possible to image subjects at sub-hundred micrometer resolution and even to trace certain chemical compounds within biological structures and soft tissues.

Within this project there is a close collaboration with BioPhysics, the WNMRC and the national ultrahigh-field Nuclear Magnetic Resonance facility (uNMR-NL).

Contact person JR (Julia) Krug MSc

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Key publications:

MRM microcoil performance calibration and usage demonstrated on Medicago truncatula roots at 22 T van Schadewijk, R., Krug, J. R., Webb, A., Van As, H., Velders, A. H., de Groot, H. J. M., Alia, A. JOVE (2021), 167, e61266
Characterizing the structure of aerobic granular sludge using ultra-high field magnetic resonance Kirkland, C. M., Krug, J. R., Vergeldt, F. J., van den Berg, L., Velders, A. H., Seymour, J. D., Codd, S. L., Van As, H., de Kreuk, M. K., Water Science & Technology (2020), 82 (4), 627-639
Assessing spatial resolution, acquisition time and signal-to-noise ratio for commercial microimaging systems at 14.1, 17.6 and 22.3 T Krug, J. R., van Schadewijk, R., Vergeldt, F. J., Webb, A. G., de Groot, H. J. M., Alia, A., Van As, H., Velders, A. H., J. Magn. Resonan. (2020),316, 106770
Magnetic resonance microscopy at cellular resolution and localised spectroscopy of Medicago truncatula at 22.3 Tesla van Schadewijk, R., Krug, J. R., Shen, D., Sankar Gupta, K. B. S., Vergeldt, F. J., Bisseling, T., Webb, A. G., Van As, H., Velders, A. H., de Groot, H. J. M., Alia, A. Scien. Rep. (2020), 10, 971
3D biofilm visualization and quantification on granular bioanodes with Magnetic Resonance Imaging Caizán-Juanarena, L., Krug, J. R., Vergeldt, F. J., Kleijn, M., Velders, A. H., Van As, H., Ter Heijne, A., Water Research (2019), 167, 115059