Publications
Method of manufacturing microdevices for lab-on-chip applications
Iuliano, Alessandro; Pijnappel, Wilhelmus Wenceslaus Matthias; Van Der Ploeg, Antje Tjitske; Saggiomo, Vittorio; De Greef, Jessica Christine; Van Der Wal, Erik; Van Der Maarel, Silvère Maria
Summary
A method of manufacturing a microstructure comprises printing a positive mold structure, filling the positive mold structure with a second material to form an elastically deformable negative mold structure, filling the negative mold structure with a third material to form the microstructure, and releasing the microstructure from the negative mold structure. Advantageously, the negative mold structure can be stretched to facilitate the release of the microstructure. For example, the microstructure comprises a chamber with capped micropillars for the generation and/or analysis of muscle tissue.